Resistance training in patients with single, large-scale deletions of mitochondrial DNA
Identifieur interne : 002237 ( Main/Exploration ); précédent : 002236; suivant : 002238Resistance training in patients with single, large-scale deletions of mitochondrial DNA
Auteurs : Julie L. Murphy [Canada] ; Emma L. Blakely [Canada] ; Andrew M. Schaefer [Canada] ; Langping He [Canada] ; Phil Wyrick [Canada] ; Ronald G. Haller [Canada] ; Robert W. Taylor [Canada] ; Douglass M. Turnbull [Canada, Royaume-Uni] ; Tanja Taivassalo [Canada]Source :
- Brain [ 0006-8950 ] ; 2008-11.
Abstract
Dramatic tissue variation in mitochondrial heteroplasmy has been found to exist in patients with sporadic mitochondrial DNA (mtDNA) mutations. Despite high abundance in mature skeletal muscle, levels of the causative mutation are low or undetectable in satellite cells. The activation of these typically quiescent mitotic cells and subsequent shifting of wild-type mtDNA templates to mature muscle have been proposed as a means of restoring a more normal mitochondrial genotype and function in these patients. Because resistance exercise is known to serve as a stimulus for satellite cell induction within active skeletal muscle, this study sought to assess the therapeutic potential of resistance training in eight patients with single, large-scale mtDNA deletions by assessing: physiological determinants of peak muscle strength and oxidative capacity and muscle biopsy-derived measures of damage, mtDNA mutation load, level of oxidative impairment and satellite cell numbers. Our results show that 12 weeks of progressive overload leg resistance training led to: (i) increased muscle strength; (ii) myofibre damage and regeneration; (iii) increased proportion of neural cell adhesion molecule (NCAM)-positive satellite cells; (iv) improved muscle oxidative capacity. Taken together, we believe these findings support the hypothesis of resistance exercise-induced mitochondrial gene-shifting in muscle containing satellite cells which have low or absent levels of deleted mtDNA. Further investigation is warranted to refine parameters of the exercise training protocol in order to maximize the training effect on mitochondrial genotype and treatment potential for patients with selected, sporadic mutations of mtDNA in skeletal muscle.
Url:
DOI: 10.1093/brain/awn252
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002189
- to stream Istex, to step Curation: 002189
- to stream Istex, to step Checkpoint: 000840
- to stream Main, to step Merge: 002430
- to stream Main, to step Curation: 002237
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Resistance training in patients with single, large-scale deletions of mitochondrial DNA</title>
<author><name sortKey="Murphy, Julie L" sort="Murphy, Julie L" uniqKey="Murphy J" first="Julie L." last="Murphy">Julie L. Murphy</name>
</author>
<author><name sortKey="Blakely, Emma L" sort="Blakely, Emma L" uniqKey="Blakely E" first="Emma L." last="Blakely">Emma L. Blakely</name>
</author>
<author><name sortKey="Schaefer, Andrew M" sort="Schaefer, Andrew M" uniqKey="Schaefer A" first="Andrew M." last="Schaefer">Andrew M. Schaefer</name>
</author>
<author><name sortKey="He, Langping" sort="He, Langping" uniqKey="He L" first="Langping" last="He">Langping He</name>
</author>
<author><name sortKey="Wyrick, Phil" sort="Wyrick, Phil" uniqKey="Wyrick P" first="Phil" last="Wyrick">Phil Wyrick</name>
</author>
<author><name sortKey="Haller, Ronald G" sort="Haller, Ronald G" uniqKey="Haller R" first="Ronald G." last="Haller">Ronald G. Haller</name>
</author>
<author><name sortKey="Taylor, Robert W" sort="Taylor, Robert W" uniqKey="Taylor R" first="Robert W." last="Taylor">Robert W. Taylor</name>
</author>
<author><name sortKey="Turnbull, Douglass M" sort="Turnbull, Douglass M" uniqKey="Turnbull D" first="Douglass M." last="Turnbull">Douglass M. Turnbull</name>
</author>
<author><name sortKey="Taivassalo, Tanja" sort="Taivassalo, Tanja" uniqKey="Taivassalo T" first="Tanja" last="Taivassalo">Tanja Taivassalo</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F095BDBF56DBD3DC82970208F0A1653D8C1539B9</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1093/brain/awn252</idno>
<idno type="url">https://api-v5.istex.fr/document/F095BDBF56DBD3DC82970208F0A1653D8C1539B9/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002189</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002189</idno>
<idno type="wicri:Area/Istex/Curation">002189</idno>
<idno type="wicri:Area/Istex/Checkpoint">000840</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000840</idno>
<idno type="wicri:doubleKey">0006-8950:2008:Murphy J:resistance:training:in</idno>
<idno type="wicri:Area/Main/Merge">002430</idno>
<idno type="wicri:Area/Main/Curation">002237</idno>
<idno type="wicri:Area/Main/Exploration">002237</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Resistance training in patients with single, large-scale deletions of mitochondrial DNA</title>
<author><name sortKey="Murphy, Julie L" sort="Murphy, Julie L" uniqKey="Murphy J" first="Julie L." last="Murphy">Julie L. Murphy</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blakely, Emma L" sort="Blakely, Emma L" uniqKey="Blakely E" first="Emma L." last="Blakely">Emma L. Blakely</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schaefer, Andrew M" sort="Schaefer, Andrew M" uniqKey="Schaefer A" first="Andrew M." last="Schaefer">Andrew M. Schaefer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="He, Langping" sort="He, Langping" uniqKey="He L" first="Langping" last="He">Langping He</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wyrick, Phil" sort="Wyrick, Phil" uniqKey="Wyrick P" first="Phil" last="Wyrick">Phil Wyrick</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haller, Ronald G" sort="Haller, Ronald G" uniqKey="Haller R" first="Ronald G." last="Haller">Ronald G. Haller</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Robert W" sort="Taylor, Robert W" uniqKey="Taylor R" first="Robert W." last="Taylor">Robert W. Taylor</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turnbull, Douglass M" sort="Turnbull, Douglass M" uniqKey="Turnbull D" first="Douglass M." last="Turnbull">Douglass M. Turnbull</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Taivassalo, Tanja" sort="Taivassalo, Tanja" uniqKey="Taivassalo T" first="Tanja" last="Taivassalo">Tanja Taivassalo</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK, The Institute for Exercise and Environmental Medicine, Dallas, TX, USA, Department of Kinesiology, McGill University and Neuromuscular Research, Montreal Neurological Institute, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2008-11">2008-11</date>
<biblScope unit="volume">131</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="2832">2832</biblScope>
<biblScope unit="page" to="2840">2840</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">F095BDBF56DBD3DC82970208F0A1653D8C1539B9</idno>
<idno type="DOI">10.1093/brain/awn252</idno>
<idno type="ArticleID">awn252</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Dramatic tissue variation in mitochondrial heteroplasmy has been found to exist in patients with sporadic mitochondrial DNA (mtDNA) mutations. Despite high abundance in mature skeletal muscle, levels of the causative mutation are low or undetectable in satellite cells. The activation of these typically quiescent mitotic cells and subsequent shifting of wild-type mtDNA templates to mature muscle have been proposed as a means of restoring a more normal mitochondrial genotype and function in these patients. Because resistance exercise is known to serve as a stimulus for satellite cell induction within active skeletal muscle, this study sought to assess the therapeutic potential of resistance training in eight patients with single, large-scale mtDNA deletions by assessing: physiological determinants of peak muscle strength and oxidative capacity and muscle biopsy-derived measures of damage, mtDNA mutation load, level of oxidative impairment and satellite cell numbers. Our results show that 12 weeks of progressive overload leg resistance training led to: (i) increased muscle strength; (ii) myofibre damage and regeneration; (iii) increased proportion of neural cell adhesion molecule (NCAM)-positive satellite cells; (iv) improved muscle oxidative capacity. Taken together, we believe these findings support the hypothesis of resistance exercise-induced mitochondrial gene-shifting in muscle containing satellite cells which have low or absent levels of deleted mtDNA. Further investigation is warranted to refine parameters of the exercise training protocol in order to maximize the training effect on mitochondrial genotype and treatment potential for patients with selected, sporadic mutations of mtDNA in skeletal muscle.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Murphy, Julie L" sort="Murphy, Julie L" uniqKey="Murphy J" first="Julie L." last="Murphy">Julie L. Murphy</name>
</noRegion>
<name sortKey="Blakely, Emma L" sort="Blakely, Emma L" uniqKey="Blakely E" first="Emma L." last="Blakely">Emma L. Blakely</name>
<name sortKey="Haller, Ronald G" sort="Haller, Ronald G" uniqKey="Haller R" first="Ronald G." last="Haller">Ronald G. Haller</name>
<name sortKey="He, Langping" sort="He, Langping" uniqKey="He L" first="Langping" last="He">Langping He</name>
<name sortKey="Schaefer, Andrew M" sort="Schaefer, Andrew M" uniqKey="Schaefer A" first="Andrew M." last="Schaefer">Andrew M. Schaefer</name>
<name sortKey="Taivassalo, Tanja" sort="Taivassalo, Tanja" uniqKey="Taivassalo T" first="Tanja" last="Taivassalo">Tanja Taivassalo</name>
<name sortKey="Taylor, Robert W" sort="Taylor, Robert W" uniqKey="Taylor R" first="Robert W." last="Taylor">Robert W. Taylor</name>
<name sortKey="Turnbull, Douglass M" sort="Turnbull, Douglass M" uniqKey="Turnbull D" first="Douglass M." last="Turnbull">Douglass M. Turnbull</name>
<name sortKey="Wyrick, Phil" sort="Wyrick, Phil" uniqKey="Wyrick P" first="Phil" last="Wyrick">Phil Wyrick</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Turnbull, Douglass M" sort="Turnbull, Douglass M" uniqKey="Turnbull D" first="Douglass M." last="Turnbull">Douglass M. Turnbull</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002237 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002237 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F095BDBF56DBD3DC82970208F0A1653D8C1539B9 |texte= Resistance training in patients with single, large-scale deletions of mitochondrial DNA }}
This area was generated with Dilib version V0.6.29. |